Clinical Practicalities for Phenotyping Oral Appliance Non-Responders-Clinical Practicalities for Phenotyping Oral Appliance Non-Responders Recording

Video Transcription

Video Summary

In this video, Dr. Jonathan Lowne discusses clinical practicalities for phenotyping oral appliance non-responders in patients with sleep-related breathing disorders. He explains the theoretical phenotypes of sleep-related breathing disorders and describes the non-anatomical factors that affect oral appliance treatment response, such as ineffective upper airway dilator muscle function, unstable respiratory control, and low respiratory arousal threshold. Dr. Lowne emphasizes the importance of collaboration with referring physicians to provide personalized treatment plans for patients. He also mentions the efficacy of oral appliances in reducing snoring and daytime sleepiness, but notes the lack of outcomes data in terms of mortality. He refers to studies on the Orange Registry, which show that oral appliance therapy can be successful in reducing the apnea hypopnea index (AHI) in a significant number of patients. He also discusses the concept of phenotype and endotype in sleep-related breathing disorders and the potential for better results with more patients. Dr. Llone suggests that understanding the distinction between phenotype and endotype can help in achieving better treatment outcomes. Overall, the video highlights the importance of individualized treatment approaches and collaboration between sleep dentists and physicians to improve patient outcomes in sleep-related breathing disorders.

Keywords

phenotyping

oral appliance non-responders

sleep-related breathing disorders

non-anatomical factors

collaboration

personalized treatment plans

oral appliances

outcomes data

phenotype